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These changes are accompanied by decreased NFκB signaling and increased NRF2 activation (Innamorato et al., 2008

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231,238,239 While the hGH:hGHr ternary complex relies on electrostatics to form a salt bridge, the interaction of hGH with hPRLr occurs through bridging via tetrahedral Zn(II) coordination of a Glu and His from hGH and Asp and His from hPRLr

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